功能: DNA metabolic process,?DNA replication,?regulation of DNA replication,?DNA repair,?base-excision repair,?base-excision repair, gap-filling,?nucleotide-excision repair,?nucleotide-excision repair, DNA gap filling,?mismatch repair,?intracellular protein transport,?response to DNA damage stimulus,?intracellular signaling cascade,?protein localization,?cell proliferation,?protein transport,?second-messenger-mediated signaling,?cellular response to stress,?cellular protein localization,?establishment of protein localization,?intracellular transport,?phosphoinositide-mediated signaling,regulation of DNA metabolic process,?cellular macromolecule localization,
細胞定位: Nucleus . Colocalizes with CREBBP, EP300 and POLD1 to sites of DNA damage (PubMed:24939902). Forms nuclear foci representing sites of ongoing DNA replication and vary in morphology and number during S phase (PubMed:15543136). Co-localizes with SMARCA5/SNF2H and BAZ1B/WSTF at replication foci during S phase (PubMed:15543136). Together with APEX2, is redistributed in discrete nuclear foci in presence of oxidative DNA damaging agents. .
功能: DNA metabolic process,?DNA replication,?regulation of DNA replication,?DNA repair,?base-excision repair,?base-excision repair, gap-filling,?nucleotide-excision repair,?nucleotide-excision repair, DNA gap filling,?mismatch repair,?intracellular protein transport,?response to DNA damage stimulus,?intracellular signaling cascade,?protein localization,?cell proliferation,?protein transport,?second-messenger-mediated signaling,?cellular response to stress,?cellular protein localization,?establishment of protein localization,?intracellular transport,?phosphoinositide-mediated signaling,regulation of DNA metabolic process,?cellular macromolecule localization,
細胞定位: Nucleus . Colocalizes with CREBBP, EP300 and POLD1 to sites of DNA damage (PubMed:24939902). Forms nuclear foci representing sites of ongoing DNA replication and vary in morphology and number during S phase (PubMed:15543136). Co-localizes with SMARCA5/SNF2H and BAZ1B/WSTF at replication foci during S phase (PubMed:15543136). Together with APEX2, is redistributed in discrete nuclear foci in presence of oxidative DNA damaging agents. .