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DOLK rabbit pAb
商品貨號： PLA020732
適 應(yīng) 性： 人,小鼠
WB
￥600元
規(guī)格：
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MSDS
說明書
商品描述
  • 基因名稱： DOLK KIAA1094 TMEM15 UNQ2422/PRO4980
  • 蛋白名稱： DOLK
  • Human_gene_id： 22845
  • Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=22845
  • Human_swiss_prot_no： Q9UPQ8
  • Human_swiss_link： https://www.uniprot.org/uniprotkb/Q9UPQ8/entry
  • Mouse_gene_id： 227697
  • Mouse_gene_link： https://www.uniprot.org/uniprot/227697
  • Mouse_swiss_prot_no： Q8R2Y3
  • Mouse_swiss_link： https://www.uniprot.org/uniprotkb/Q8R2Y3
  • 特異性： This antibody detects endogenous levels of DOLK at Human/Mouse
  • 組成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 來源： Polyclonal, Rabbit,IgG
  • 稀釋： WB 1：500-2000
  • 純化工藝： The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度： 1 mg/ml
  • 儲存： -15°C to -25°C/1 year(Do not lower than -25°C)
  • 說明書： 1
  • Msds： MSDS_Antibody.pdf
  • 分子量： 59kD
  • 功能： catalytic activity:CTP + dolichol = CDP + dolichyl phosphate.,disease:Defects in DOLK are the cause of congenital disorder of glycosylation type 1M (CDG1M) [MIM:610768]; also known as dolichol kinase deficiency. CDGs are a family of severe inherited diseases caused by a defect in glycoprotein biosynthesis. They are characterized by under-glycosylated serum glycoproteins. These multisystem disorders present with a wide variety of clinical features, such as disorders of the nervous system development, psychomotor retardation, dysmorphic features, hypotonia, coagulation disorders, and immunodeficiency. The broad spectrum of features reflects the critical role of N-glycoproteins during embryonic development, differentiation, and maintenance of cell functions. CDG1M is a very severe disorder with death occurring in early infancy.,function:Involved in the synthesis of the sugar donor Dol-P-Man which is required in the synthesis of N-linked and O-linked oligosaccharides and for that of GPI anchors.,miscellaneous:Complements the defects in growth, dolichol kinase activity and protein N-glycosylation at the restrictive temperature in yeast sec59 mutant cells.,similarity:Belongs to the polyprenol kinase family.,tissue specificity:Ubiquitous.,
  • 相關(guān)產(chǎn)品： RS0001,RS0002,YM3028,YM3029
  • 細胞定位： Endoplasmic reticulum membrane ; Multi-pass membrane protein .
  • 組織表達： Ubiquitous.
  • 科研貨號： PLA020732
DOLK rabbit pAb
Catalog No PLA020732
Product information
  • 基因名稱： DOLK KIAA1094 TMEM15 UNQ2422/PRO4980
  • 蛋白名稱： DOLK
  • Human_gene_id： 22845
  • Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=22845
  • Human_swiss_prot_no： Q9UPQ8
  • Human_swiss_link： https://www.uniprot.org/uniprotkb/Q9UPQ8/entry
  • Mouse_gene_id： 227697
  • Mouse_gene_link： https://www.uniprot.org/uniprot/227697
  • Mouse_swiss_prot_no： Q8R2Y3
  • Mouse_swiss_link： https://www.uniprot.org/uniprotkb/Q8R2Y3
  • 特異性： This antibody detects endogenous levels of DOLK at Human/Mouse
  • 組成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 來源： Polyclonal, Rabbit,IgG
  • 稀釋： WB 1：500-2000
  • 純化工藝： The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度： 1 mg/ml
  • 儲存： -15°C to -25°C/1 year(Do not lower than -25°C)
  • 說明書： 1
  • Msds： MSDS_Antibody.pdf
  • 分子量： 59kD
  • 功能： catalytic activity:CTP + dolichol = CDP + dolichyl phosphate.,disease:Defects in DOLK are the cause of congenital disorder of glycosylation type 1M (CDG1M) [MIM:610768]; also known as dolichol kinase deficiency. CDGs are a family of severe inherited diseases caused by a defect in glycoprotein biosynthesis. They are characterized by under-glycosylated serum glycoproteins. These multisystem disorders present with a wide variety of clinical features, such as disorders of the nervous system development, psychomotor retardation, dysmorphic features, hypotonia, coagulation disorders, and immunodeficiency. The broad spectrum of features reflects the critical role of N-glycoproteins during embryonic development, differentiation, and maintenance of cell functions. CDG1M is a very severe disorder with death occurring in early infancy.,function:Involved in the synthesis of the sugar donor Dol-P-Man which is required in the synthesis of N-linked and O-linked oligosaccharides and for that of GPI anchors.,miscellaneous:Complements the defects in growth, dolichol kinase activity and protein N-glycosylation at the restrictive temperature in yeast sec59 mutant cells.,similarity:Belongs to the polyprenol kinase family.,tissue specificity:Ubiquitous.,
  • 相關(guān)產(chǎn)品： RS0001,RS0002,YM3028,YM3029
  • 細胞定位： Endoplasmic reticulum membrane ; Multi-pass membrane protein .
  • 組織表達： Ubiquitous.
  • 科研貨號： PLA020732
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