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ATF6A rabbit pAb
商品貨號： PLA021058
適 應(yīng) 性： 人,大鼠,小鼠,
WB
￥600元
規(guī)格：
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MSDS
說明書
商品描述
  • 基因名稱： ATF6
  • 蛋白名稱： ATF6A
  • Human_gene_id： 22926
  • Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=22926
  • Human_swiss_prot_no： P18850
  • Human_swiss_link： https://www.uniprot.org/uniprotkb/P18850/entry
  • 特異性： This antibody detects endogenous levels of ATF6A at Human
  • 組成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 來源： Polyclonal, Rabbit,IgG
  • 稀釋： WB 1：500-2000
  • 純化工藝： The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度： 1 mg/ml
  • 儲存： -15°C to -25°C/1 year(Do not lower than -25°C)
  • 說明書： 1
  • Msds： MSDS_Antibody.pdf
  • 實測條帶： 90kD
  • 功能： domain:The basic domain functions as a nuclear localization signal.,domain:The basic leucine-zipper domain is sufficient for association with the NF-Y trimer and binding to ERSE.,function:Transcription factor that acts during endoplasmic reticulum stress by activating unfolded protein response target genes. Binds DNA on the 5'-CCAC[GA]-3'half of the ER stress response element (ERSE) (5'-CCAAT-N(9)-CCAC[GA]-3') and of ERSE II (5'-ATTGG-N-CCACG-3'). Binding to ERSE requires binding of NF-Y to ERSE. Could also be involved in activation of transcription by the serum response factor.,PTM:During unfolded protein response an approximative 50 kDa fragment containing the cytoplasmic transcription factor domain is released by proteolysis. The cleavage seems to be performed sequentially by site-1 and site-2 proteases.,PTM:N-glycosylated.,PTM:Phosphorylated in vitro by MAPK14/P38MAPK.,similarity:Belongs to the bZIP family.,similarity:Belongs to the bZIP family. ATF subfamily.,similarity:Contains 1 bZIP domain.,subcellular location:Under ER stress the cleaved N-terminal cytoplasmic domain translocates into the nucleus.,subunit:Homodimer and heterodimer with ATF6-beta. The dimer interacts with the nuclear transcription factor Y (NF-Y) trimer through direct binding to NF-Y subunit C (NF-YC). Interacts also with the transcription factors GTF2I, YY1 and SRF.,tissue specificity:Ubiquitous.,
  • 相關(guān)產(chǎn)品： RS0001,RS0002,YM3028,YM3029
  • 細(xì)胞定位： Endoplasmic reticulum membrane ; Single-pass type II membrane protein . Golgi apparatus membrane ; Single-pass type II membrane protein . Translocates from the endoplasmic reticulum to the Golgi, where it is processed. .; [Processed cyclic AMP-dependent transcription factor ATF-6 alpha]: Nucleus . Under ER stress the cleaved N-terminal cytoplasmic domain translocates into the nucleus (PubMed:10564271, PubMed:12782636). THBS4 promotes its nuclear shuttling (By similarity). .
  • 組織表達(dá)： Ubiquitous.
  • 科研貨號： PLA021058
ATF6A rabbit pAb
Catalog No PLA021058
Product information
  • 基因名稱： ATF6
  • 蛋白名稱： ATF6A
  • Human_gene_id： 22926
  • Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=22926
  • Human_swiss_prot_no： P18850
  • Human_swiss_link： https://www.uniprot.org/uniprotkb/P18850/entry
  • 特異性： This antibody detects endogenous levels of ATF6A at Human
  • 組成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 來源： Polyclonal, Rabbit,IgG
  • 稀釋： WB 1：500-2000
  • 純化工藝： The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度： 1 mg/ml
  • 儲存： -15°C to -25°C/1 year(Do not lower than -25°C)
  • 說明書： 1
  • Msds： MSDS_Antibody.pdf
  • 實測條帶： 90kD
  • 功能： domain:The basic domain functions as a nuclear localization signal.,domain:The basic leucine-zipper domain is sufficient for association with the NF-Y trimer and binding to ERSE.,function:Transcription factor that acts during endoplasmic reticulum stress by activating unfolded protein response target genes. Binds DNA on the 5'-CCAC[GA]-3'half of the ER stress response element (ERSE) (5'-CCAAT-N(9)-CCAC[GA]-3') and of ERSE II (5'-ATTGG-N-CCACG-3'). Binding to ERSE requires binding of NF-Y to ERSE. Could also be involved in activation of transcription by the serum response factor.,PTM:During unfolded protein response an approximative 50 kDa fragment containing the cytoplasmic transcription factor domain is released by proteolysis. The cleavage seems to be performed sequentially by site-1 and site-2 proteases.,PTM:N-glycosylated.,PTM:Phosphorylated in vitro by MAPK14/P38MAPK.,similarity:Belongs to the bZIP family.,similarity:Belongs to the bZIP family. ATF subfamily.,similarity:Contains 1 bZIP domain.,subcellular location:Under ER stress the cleaved N-terminal cytoplasmic domain translocates into the nucleus.,subunit:Homodimer and heterodimer with ATF6-beta. The dimer interacts with the nuclear transcription factor Y (NF-Y) trimer through direct binding to NF-Y subunit C (NF-YC). Interacts also with the transcription factors GTF2I, YY1 and SRF.,tissue specificity:Ubiquitous.,
  • 相關(guān)產(chǎn)品： RS0001,RS0002,YM3028,YM3029
  • 細(xì)胞定位： Endoplasmic reticulum membrane ; Single-pass type II membrane protein . Golgi apparatus membrane ; Single-pass type II membrane protein . Translocates from the endoplasmic reticulum to the Golgi, where it is processed. .; [Processed cyclic AMP-dependent transcription factor ATF-6 alpha]: Nucleus . Under ER stress the cleaved N-terminal cytoplasmic domain translocates into the nucleus (PubMed:10564271, PubMed:12782636). THBS4 promotes its nuclear shuttling (By similarity). .
  • 組織表達(dá)： Ubiquitous.
  • 科研貨號： PLA021058
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