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ZFP57 rabbit pAb
商品貨號(hào)： PLA021117
適 應(yīng) 性： 人,小鼠,大鼠
WB
￥600元
規(guī)格：
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MSDS
說(shuō)明書(shū)
商品描述
  • 基因名稱(chēng)： ZFP57 C6orf40 ZNF698
  • 蛋白名稱(chēng)： ZFP57
  • Human_gene_id： 346171
  • Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=346171
  • Human_swiss_prot_no： Q9NU63
  • Human_swiss_link： https://www.uniprot.org/uniprotkb/Q9NU63/entry
  • Mouse_gene_id： 22715
  • Mouse_gene_link： https://www.uniprot.org/uniprot/22715
  • Mouse_swiss_prot_no： Q8C6P8
  • Mouse_swiss_link： https://www.uniprot.org/uniprotkb/Q8C6P8
  • Rat_gene_id： 361783
  • Rat_gene_link： https://www.uniprot.org/uniprot/361783
  • Rat_swiss_prot_no： A0JPK3
  • Rat_swiss_link： https://www.uniprot.org/uniprotkb/A0JPK3
  • 特異性： This antibody detects endogenous levels of ZFP57 at Human/Mouse/Rat
  • 組成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 來(lái)源： Polyclonal, Rabbit,IgG
  • 稀釋?zhuān)? WB 1：500-2000
  • 純化工藝： The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度： 1 mg/ml
  • 儲(chǔ)存： -15°C to -25°C/1 year(Do not lower than -25°C)
  • 說(shuō)明書(shū)： 1
  • Msds： MSDS_Antibody.pdf
  • 分子量： 50kD
  • 功能： disease:Defects in ZFP57 are the cause of transient neonatal diabetes mellitus type 1 (TNDM1) [MIM:601410]. Neonatal diabetes is a form of diabetes mellitus defined by the onset of mild-to-severe hyperglycemia within the first months of life. In about half of the neonates, diabetes is transient and resolves at a median age of 3 months, whereas the rest have a permanent form of diabetes. The major cause of TNDM1 is aberrant expression of imprinted genes at chromosome 6q24, associated in 20% of cases with DNA hypomethylation at the transient neonatal diabetes differentially methylated region (DMR), which lies within the imprinted promoter of the PLAGL1 gene. Over 50% of individuals with transient neonatal diabetes and hypomethylation at 6q24 also show mosaic DNA hypomethylation at other imprinted loci throughout the genome and a range of additional clinical features.,domain:The KRAB domain is required for function as transcriptional repressor.,function:Transcription regulator required to maintain maternal and paternal gene imprinting, a process by which gene expression is restricted in a parent of origin-specific manner by epigenetic modification of genomic DNA and chromatin, including DNA methylation. Acts by controlling DNA methylation during the earliest multicellular stages of development at multiple imprinting control regions. Required for the establishment of maternal methylation imprints at SNRPN locus. Acts as a transcriptional repressor in Schwann cells.,similarity:Belongs to the krueppel C2H2-type zinc-finger protein family. ZFP57 subfamily.,similarity:Contains 1 KRAB domain.,similarity:Contains 7 C2H2-type zinc fingers.,subcellular location:Binds various differentially methylated regions (DMR), including the Snrpn DMR.,
  • 相關(guān)產(chǎn)品： RS0001,RS0002,YM3028,YM3029
  • 細(xì)胞定位： Nucleus . Binds various differentially methylated regions (DMR). .
  • 科研貨號(hào)： PLA021117
ZFP57 rabbit pAb
Catalog No PLA021117
Product information
  • 基因名稱(chēng)： ZFP57 C6orf40 ZNF698
  • 蛋白名稱(chēng)： ZFP57
  • Human_gene_id： 346171
  • Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=346171
  • Human_swiss_prot_no： Q9NU63
  • Human_swiss_link： https://www.uniprot.org/uniprotkb/Q9NU63/entry
  • Mouse_gene_id： 22715
  • Mouse_gene_link： https://www.uniprot.org/uniprot/22715
  • Mouse_swiss_prot_no： Q8C6P8
  • Mouse_swiss_link： https://www.uniprot.org/uniprotkb/Q8C6P8
  • Rat_gene_id： 361783
  • Rat_gene_link： https://www.uniprot.org/uniprot/361783
  • Rat_swiss_prot_no： A0JPK3
  • Rat_swiss_link： https://www.uniprot.org/uniprotkb/A0JPK3
  • 特異性： This antibody detects endogenous levels of ZFP57 at Human/Mouse/Rat
  • 組成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 來(lái)源： Polyclonal, Rabbit,IgG
  • 稀釋?zhuān)? WB 1：500-2000
  • 純化工藝： The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度： 1 mg/ml
  • 儲(chǔ)存： -15°C to -25°C/1 year(Do not lower than -25°C)
  • 說(shuō)明書(shū)： 1
  • Msds： MSDS_Antibody.pdf
  • 分子量： 50kD
  • 功能： disease:Defects in ZFP57 are the cause of transient neonatal diabetes mellitus type 1 (TNDM1) [MIM:601410]. Neonatal diabetes is a form of diabetes mellitus defined by the onset of mild-to-severe hyperglycemia within the first months of life. In about half of the neonates, diabetes is transient and resolves at a median age of 3 months, whereas the rest have a permanent form of diabetes. The major cause of TNDM1 is aberrant expression of imprinted genes at chromosome 6q24, associated in 20% of cases with DNA hypomethylation at the transient neonatal diabetes differentially methylated region (DMR), which lies within the imprinted promoter of the PLAGL1 gene. Over 50% of individuals with transient neonatal diabetes and hypomethylation at 6q24 also show mosaic DNA hypomethylation at other imprinted loci throughout the genome and a range of additional clinical features.,domain:The KRAB domain is required for function as transcriptional repressor.,function:Transcription regulator required to maintain maternal and paternal gene imprinting, a process by which gene expression is restricted in a parent of origin-specific manner by epigenetic modification of genomic DNA and chromatin, including DNA methylation. Acts by controlling DNA methylation during the earliest multicellular stages of development at multiple imprinting control regions. Required for the establishment of maternal methylation imprints at SNRPN locus. Acts as a transcriptional repressor in Schwann cells.,similarity:Belongs to the krueppel C2H2-type zinc-finger protein family. ZFP57 subfamily.,similarity:Contains 1 KRAB domain.,similarity:Contains 7 C2H2-type zinc fingers.,subcellular location:Binds various differentially methylated regions (DMR), including the Snrpn DMR.,
  • 相關(guān)產(chǎn)品： RS0001,RS0002,YM3028,YM3029
  • 細(xì)胞定位： Nucleus . Binds various differentially methylated regions (DMR). .
  • 科研貨號(hào)： PLA021117
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