其他名稱： Werner syndrome ATP-dependent helicase (EC 3.6.4.12;DNA helicase, RecQ-like type 3;RecQ3;Exonuclease WRN;EC 3.1.-.-;RecQ protein-like 2)
分子量： 158kD
功能： disease:Defects in WRN are a cause of Werner syndrome (WRN) [MIM:277700]. WRN is a rare autosomal recessive progeroid syndrome characterized by the premature onset of multiple age-related disorders, including atherosclerosis, cancer, non-insulin-dependent diabetes mellitus, ocular cataracts and osteoporosis. The major cause of death, at a median age of 47, is myocardial infarction. Currently all known WS mutations produces prematurely terminated proteins.,disease:Defects in WRN may be a cause of colorectal cancer (CRC) [MIM:114500].,function:Essential for the formation of DNA replication focal centers; stably associates with foci elements generating binding sites for RP-A. Exhibits a magnesium-dependent ATP-dependent DNA-helicase activity. May be involved in the control of genomic stability.,online information:WRN mutation db (Warner disease),PTM:Phosphorylated by PRKDC. Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the helicase family. RecQ subfamily.,similarity:Contains 1 3'-5' exonuclease domain.,similarity:Contains 1 helicase ATP-binding domain.,similarity:Contains 1 helicase C-terminal domain.,similarity:Contains 1 HRDC domain.,subunit:Interacts via its N-terminal domain with WRNIP1 (By similarity). Interacts with EXO1.,
相關產品： RS0001,RS0002,YM3028,YM3289
細胞定位： Nucleus, nucleolus . Nucleus . Nucleus, nucleoplasm . Chromosome . Gamma-irradiation leads to its translocation from nucleoli to nucleoplasm and PML regulates the irradiation-induced WRN relocation (PubMed:21639834). Localizes to DNA damage sites (PubMed:27063109). .
其他名稱： Werner syndrome ATP-dependent helicase (EC 3.6.4.12;DNA helicase, RecQ-like type 3;RecQ3;Exonuclease WRN;EC 3.1.-.-;RecQ protein-like 2)
分子量： 158kD
功能： disease:Defects in WRN are a cause of Werner syndrome (WRN) [MIM:277700]. WRN is a rare autosomal recessive progeroid syndrome characterized by the premature onset of multiple age-related disorders, including atherosclerosis, cancer, non-insulin-dependent diabetes mellitus, ocular cataracts and osteoporosis. The major cause of death, at a median age of 47, is myocardial infarction. Currently all known WS mutations produces prematurely terminated proteins.,disease:Defects in WRN may be a cause of colorectal cancer (CRC) [MIM:114500].,function:Essential for the formation of DNA replication focal centers; stably associates with foci elements generating binding sites for RP-A. Exhibits a magnesium-dependent ATP-dependent DNA-helicase activity. May be involved in the control of genomic stability.,online information:WRN mutation db (Warner disease),PTM:Phosphorylated by PRKDC. Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the helicase family. RecQ subfamily.,similarity:Contains 1 3'-5' exonuclease domain.,similarity:Contains 1 helicase ATP-binding domain.,similarity:Contains 1 helicase C-terminal domain.,similarity:Contains 1 HRDC domain.,subunit:Interacts via its N-terminal domain with WRNIP1 (By similarity). Interacts with EXO1.,
相關產品： RS0001,RS0002,YM3028,YM3289
細胞定位： Nucleus, nucleolus . Nucleus . Nucleus, nucleoplasm . Chromosome . Gamma-irradiation leads to its translocation from nucleoli to nucleoplasm and PML regulates the irradiation-induced WRN relocation (PubMed:21639834). Localizes to DNA damage sites (PubMed:27063109). .
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