其他名稱： YTH domain-containing protein 1 (Putative splicing factor YT521)
分子量： 80kD
功能： Regulator of alternative splicing that specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs . M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in the efficiency of mRNA splicing, processing and stability . Acts as a key regulator of exon-inclusion or exon-skipping during alternative splicing via interaction with mRNA splicing factors SRSF3 and SRSF10 . Specifically binds m6A-containing mRNAs and promotes recruitment of SRSF3 to its mRNA-binding elements adjacent to m6A sites, leading to exon-inclusion during alternative splicing . In contrast, interaction with SRSF3 prevents interaction with SRSF10, a splicing factor that promotes exon skipping: this prevents SRSF10 from binding to its mRNA-binding sites close to m6A-containing regions, leading to inhibit exon skipping during alternative splicing . May also regulate alternative splice site selection . Also involved in nuclear export of m6A-containing mRNAs via interaction with SRSF3: interaction with SRSF3 facilitates m6A-containing mRNA-binding to both SRSF3 and NXF1, promoting mRNA nuclear export . Involved in S-adenosyl-L-methionine homeostasis by regulating expression of MAT2A transcripts, probably by binding m6A-containing MAT2A mRNAs (By similarity). Also recognizes and binds m6A on other RNA molecules . Involved in random X inactivation mediated by Xist RNA: recognizes and binds m6A-containing Xist and promotes transcription repression activity of Xist . Also recognizes and binds m6A-containing single-stranded DNA . Involved in germline development: required for spermatogonial development in males and oocyte growth and maturation in females, probably via its role in alternative splicing (By similarity).
相關產品： RS0001,RS0002,YM3028,YM3029
細胞定位： Nucleus . Nucleus speckle . Localizes to a novel subnuclear structure, the YT bodies. .
科研貨號： PLA021554
YTDC1 rabbit pAb
Catalog NoPLA021554
Product information
基因名稱： YTHDC1 KIAA1966 YT521
蛋白名稱： YTH domain-containing protein 1 (Putative splicing factor YT521)
其他名稱： YTH domain-containing protein 1 (Putative splicing factor YT521)
分子量： 80kD
功能： Regulator of alternative splicing that specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs . M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in the efficiency of mRNA splicing, processing and stability . Acts as a key regulator of exon-inclusion or exon-skipping during alternative splicing via interaction with mRNA splicing factors SRSF3 and SRSF10 . Specifically binds m6A-containing mRNAs and promotes recruitment of SRSF3 to its mRNA-binding elements adjacent to m6A sites, leading to exon-inclusion during alternative splicing . In contrast, interaction with SRSF3 prevents interaction with SRSF10, a splicing factor that promotes exon skipping: this prevents SRSF10 from binding to its mRNA-binding sites close to m6A-containing regions, leading to inhibit exon skipping during alternative splicing . May also regulate alternative splice site selection . Also involved in nuclear export of m6A-containing mRNAs via interaction with SRSF3: interaction with SRSF3 facilitates m6A-containing mRNA-binding to both SRSF3 and NXF1, promoting mRNA nuclear export . Involved in S-adenosyl-L-methionine homeostasis by regulating expression of MAT2A transcripts, probably by binding m6A-containing MAT2A mRNAs (By similarity). Also recognizes and binds m6A on other RNA molecules . Involved in random X inactivation mediated by Xist RNA: recognizes and binds m6A-containing Xist and promotes transcription repression activity of Xist . Also recognizes and binds m6A-containing single-stranded DNA . Involved in germline development: required for spermatogonial development in males and oocyte growth and maturation in females, probably via its role in alternative splicing (By similarity).
相關產品： RS0001,RS0002,YM3028,YM3029
細胞定位： Nucleus . Nucleus speckle . Localizes to a novel subnuclear structure, the YT bodies. .
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