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PDPK1 (Phospho Ser241) Rabbit mAb
商品貨號： PRM8022
適 應 性： 人,小鼠,大鼠
WB IF ELISA IP
￥7000元
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商品描述
  • 發貨日期： 現貨
  • 靶點-Target： PDPK1
  • 反應性-Reactivity： 人,小鼠,大鼠
  • 應用-Applications： WB,IF,IP,ELISA
  • MW(Calculated)： 63kD
  • MW(Observed)： 63kD
  • 宿主物種-Host Species： Rabbit
  • 同種型-Isotype： IgG,Kappa
  • 偶聯-Conjugate： Phospho
  • 修飾-Modification： Ser241
  • 推薦稀釋比： WB 1:2000-1:10000;IF 1:200-1:1000;ELISA 1:5000-1:20000;IP 1:50-1:200;
  • 組成： PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
  • 純化工藝： Protein A
  • 儲存： -15°C to -25°C/1 year(Do not lower than -25°C)
  • 克隆性： Monoclonal
  • 克隆號： PT0869R
  • 特異性： Phospho-PDK1 (S241) Antibody detects endogenous levels of PDK1 protein only when phosphorylated at S241.The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):ANsFV
  • 基因名稱： PDPK1
  • 蛋白名稱： 3-phosphoinositide-dependent protein kinase 1
  • 別名： PDPK1;PDK1;3-phosphoinositide-dependent protein kinase 1;hPDK1
  • Organism-1： Human
  • 基因ID-1： 5170
  • SwissProt-1： O15530
  • Organism-2： Mouse
  • 基因ID-2： 18607
  • SwissProt-2： Q9Z2A0
  • Organism-3： Rat
  • 基因ID-3： 81745
  • SwissProt-3： O55173
  • 背景： catalytic activity:ATP + a protein = ADP + a phosphoprotein.,function:Phosphorylates and activates not only PKB/AKT, but also PKA, PKC-zeta, RPS6KA1 and RPS6KB1. May play a general role in signaling processes and in development (By similarity). Isoform 3 is catalytically inactive.,PTM:Phosphorylated on tyrosine and serine/threonine. Phosphorylation on Ser-241 in the activation loop is required for full activity. PDK1 itself can autophosphorylate Ser-241, leading to its own activation.,similarity:Belongs to the protein kinase superfamily.,similarity:Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PDK1 subfamily.,similarity:Contains 1 PH domain.,similarity:Contains 1 protein kinase domain.,subcellular location:Membrane-associated after cell stimulation leading to its translocation. Tyrosine phosphorylation seems to occur only at the plasma membrane.,subunit:Interacts with TUSC4.,tissue specificity:Appears to be expressed ubiquitously.,
  • 細胞定位： Cytoplasm. Nucleus. Cell membrane; Peripheral membrane protein. Cell junction, focal adhesion. Tyrosine phosphorylation seems to occur only at the cell membrane. Translocates to the cell membrane following insulin stimulation by a mechanism that involves binding to GRB14 and INSR. SRC and HSP90 promote its localization to the cell membrane. Its nuclear localization is dependent on its association with PTPN6 and its phosphorylation at Ser-396. Restricted to the nucleus in neuronal cells while in non-neuronal cells it is found in the cytoplasm. The Ser-241 phosphorylated form is distributed along the perinuclear region in neuronal cells while in non-neuronal cells it is found in both the nucleus and the cytoplasm. IGF1 transiently increases phosphorylation at Ser-241 of neuronal PDPK1, resulting in its translocation to other cellular compartments. The tyrosine-phosphorylated form colocalizes with PTK2B in focal adhesions after angiotensin II stimulation.
PDPK1 (Phospho Ser241) Rabbit mAb
Catalog No PRM8022
Product information
  • 發貨日期： 現貨
  • 靶點-Target： PDPK1
  • 反應性-Reactivity： 人,小鼠,大鼠
  • 應用-Applications： WB,IF,IP,ELISA
  • MW(Calculated)： 63kD
  • MW(Observed)： 63kD
  • 宿主物種-Host Species： Rabbit
  • 同種型-Isotype： IgG,Kappa
  • 偶聯-Conjugate： Phospho
  • 修飾-Modification： Ser241
  • 推薦稀釋比： WB 1:2000-1:10000;IF 1:200-1:1000;ELISA 1:5000-1:20000;IP 1:50-1:200;
  • 組成： PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
  • 純化工藝： Protein A
  • 儲存： -15°C to -25°C/1 year(Do not lower than -25°C)
  • 克隆性： Monoclonal
  • 克隆號： PT0869R
  • 特異性： Phospho-PDK1 (S241) Antibody detects endogenous levels of PDK1 protein only when phosphorylated at S241.The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):ANsFV
  • 基因名稱： PDPK1
  • 蛋白名稱： 3-phosphoinositide-dependent protein kinase 1
  • 別名： PDPK1;PDK1;3-phosphoinositide-dependent protein kinase 1;hPDK1
  • Organism-1： Human
  • 基因ID-1： 5170
  • SwissProt-1： O15530
  • Organism-2： Mouse
  • 基因ID-2： 18607
  • SwissProt-2： Q9Z2A0
  • Organism-3： Rat
  • 基因ID-3： 81745
  • SwissProt-3： O55173
  • 背景： catalytic activity:ATP + a protein = ADP + a phosphoprotein.,function:Phosphorylates and activates not only PKB/AKT, but also PKA, PKC-zeta, RPS6KA1 and RPS6KB1. May play a general role in signaling processes and in development (By similarity). Isoform 3 is catalytically inactive.,PTM:Phosphorylated on tyrosine and serine/threonine. Phosphorylation on Ser-241 in the activation loop is required for full activity. PDK1 itself can autophosphorylate Ser-241, leading to its own activation.,similarity:Belongs to the protein kinase superfamily.,similarity:Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PDK1 subfamily.,similarity:Contains 1 PH domain.,similarity:Contains 1 protein kinase domain.,subcellular location:Membrane-associated after cell stimulation leading to its translocation. Tyrosine phosphorylation seems to occur only at the plasma membrane.,subunit:Interacts with TUSC4.,tissue specificity:Appears to be expressed ubiquitously.,
  • 細胞定位： Cytoplasm. Nucleus. Cell membrane; Peripheral membrane protein. Cell junction, focal adhesion. Tyrosine phosphorylation seems to occur only at the cell membrane. Translocates to the cell membrane following insulin stimulation by a mechanism that involves binding to GRB14 and INSR. SRC and HSP90 promote its localization to the cell membrane. Its nuclear localization is dependent on its association with PTPN6 and its phosphorylation at Ser-396. Restricted to the nucleus in neuronal cells while in non-neuronal cells it is found in the cytoplasm. The Ser-241 phosphorylated form is distributed along the perinuclear region in neuronal cells while in non-neuronal cells it is found in both the nucleus and the cytoplasm. IGF1 transiently increases phosphorylation at Ser-241 of neuronal PDPK1, resulting in its translocation to other cellular compartments. The tyrosine-phosphorylated form colocalizes with PTK2B in focal adhesions after angiotensin II stimulation.
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