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首頁(yè) > 抗體 > 兔單抗 > Zap-70 (Phospho Tyr319)/Syk (Phospho Tyr352) Rabbit mAb
Zap-70 (Phospho Tyr319)/Syk (Phospho Tyr352) Rabbit mAb
商品貨號(hào)： PRM8111
適 應(yīng) 性： 人,小鼠,大鼠
WB IF ELISA IP
￥7000元
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商品描述
  • 發(fā)貨日期： 現(xiàn)貨
  • 靶點(diǎn)-Target： ZAP-70/Syk
  • 反應(yīng)性-Reactivity： 人,小鼠,大鼠
  • 應(yīng)用-Applications： WB,IF,IP,ELISA
  • MW(Calculated)： 70kD
  • MW(Observed)： 70kD
  • 宿主物種-Host Species： Rabbit
  • 同種型-Isotype： IgG,Kappa
  • 偶聯(lián)-Conjugate： Phospho
  • 修飾-Modification： Tyr319/Tyr352
  • 推薦稀釋比： WB 1:2000-1:10000;IF 1:200-1:1000;ELISA 1:5000-1:20000;IP 1:50-1:200;
  • 組成： PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
  • 純化工藝： Protein A
  • 儲(chǔ)存： -15°C to -25°C/1 year(Do not lower than -25°C)
  • 克隆性： Monoclonal
  • 克隆號(hào)： PT0710R
  • 特異性： The antibody detects endogenous ZAP-70/Syk(Phospho AE13) protein.
  • 基因名稱： ZAP70/SYK
  • 蛋白名稱： Tyrosine-protein kinase ZAP-70/Tyrosine-protein kinase SYK
  • 別名： ZAP70;SRK;Tyrosine-protein kinase ZAP-70;70 kDa zeta-chain associated protein;Syk-related tyrosine kinase;SYK;Tyrosine-protein kinase SYK;Spleen tyrosine kinase;p72-Syk;
  • Organism-1： Human
  • 基因ID-1： 7535;6850
  • SwissProt-1： P43403;P43405
  • Organism-2： Mouse
  • 基因ID-2： 22637;20963
  • SwissProt-2： P43404;P48025
  • 背景： ZAP70 gene encodes an enzyme belonging to the protein tyrosine kinase family, and it plays a role in T-cell development and lymphocyte activation. This enzyme, which is phosphorylated on tyrosine residues upon T-cell antigen receptor (TCR) stimulation, functions in the initial step of TCR-mediated signal transduction in combination with the Src family kinases, Lck and Fyn. This enzyme is also essential for thymocyte development. Mutations in this gene cause selective T-cell defect, a severe combined immunodeficiency disease characterized by a selective absence of CD8-positive T-cells. Two transcript variants that encode different isoforms have been found for this gene. [provided by RefSeq, Jul 2008],SYK gene encodes a member of the family of non-receptor type Tyr protein kinases. This protein is widely expressed in hematopoietic cells and is involved in coupling activated immunoreceptors to downstream signaling events that mediate diverse cellular responses, including proliferation, differentiation, and phagocytosis. It is thought to be a modulator of epithelial cell growth and a potential tumour suppressor in human breast carcinomas. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010],
  • 細(xì)胞定位： Cytoplasm . Cell membrane ; Peripheral membrane protein . In quiescent T-lymphocytes, it is cytoplasmic. Upon TCR activation, it is recruited at the plasma membrane by interacting with CD247/CD3Z. Colocalizes together with RHOH in the immunological synapse. RHOH is required for its proper localization to the cell membrane and cytoskeleton fractions in the thymocytes (By similarity). cytosol .
Zap-70 (Phospho Tyr319)/Syk (Phospho Tyr352) Rabbit mAb
Catalog No PRM8111
Product information
  • 發(fā)貨日期： 現(xiàn)貨
  • 靶點(diǎn)-Target： ZAP-70/Syk
  • 反應(yīng)性-Reactivity： 人,小鼠,大鼠
  • 應(yīng)用-Applications： WB,IF,IP,ELISA
  • MW(Calculated)： 70kD
  • MW(Observed)： 70kD
  • 宿主物種-Host Species： Rabbit
  • 同種型-Isotype： IgG,Kappa
  • 偶聯(lián)-Conjugate： Phospho
  • 修飾-Modification： Tyr319/Tyr352
  • 推薦稀釋比： WB 1:2000-1:10000;IF 1:200-1:1000;ELISA 1:5000-1:20000;IP 1:50-1:200;
  • 組成： PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
  • 純化工藝： Protein A
  • 儲(chǔ)存： -15°C to -25°C/1 year(Do not lower than -25°C)
  • 克隆性： Monoclonal
  • 克隆號(hào)： PT0710R
  • 特異性： The antibody detects endogenous ZAP-70/Syk(Phospho AE13) protein.
  • 基因名稱： ZAP70/SYK
  • 蛋白名稱： Tyrosine-protein kinase ZAP-70/Tyrosine-protein kinase SYK
  • 別名： ZAP70;SRK;Tyrosine-protein kinase ZAP-70;70 kDa zeta-chain associated protein;Syk-related tyrosine kinase;SYK;Tyrosine-protein kinase SYK;Spleen tyrosine kinase;p72-Syk;
  • Organism-1： Human
  • 基因ID-1： 7535;6850
  • SwissProt-1： P43403;P43405
  • Organism-2： Mouse
  • 基因ID-2： 22637;20963
  • SwissProt-2： P43404;P48025
  • 背景： ZAP70 gene encodes an enzyme belonging to the protein tyrosine kinase family, and it plays a role in T-cell development and lymphocyte activation. This enzyme, which is phosphorylated on tyrosine residues upon T-cell antigen receptor (TCR) stimulation, functions in the initial step of TCR-mediated signal transduction in combination with the Src family kinases, Lck and Fyn. This enzyme is also essential for thymocyte development. Mutations in this gene cause selective T-cell defect, a severe combined immunodeficiency disease characterized by a selective absence of CD8-positive T-cells. Two transcript variants that encode different isoforms have been found for this gene. [provided by RefSeq, Jul 2008],SYK gene encodes a member of the family of non-receptor type Tyr protein kinases. This protein is widely expressed in hematopoietic cells and is involved in coupling activated immunoreceptors to downstream signaling events that mediate diverse cellular responses, including proliferation, differentiation, and phagocytosis. It is thought to be a modulator of epithelial cell growth and a potential tumour suppressor in human breast carcinomas. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010],
  • 細(xì)胞定位： Cytoplasm . Cell membrane ; Peripheral membrane protein . In quiescent T-lymphocytes, it is cytoplasmic. Upon TCR activation, it is recruited at the plasma membrane by interacting with CD247/CD3Z. Colocalizes together with RHOH in the immunological synapse. RHOH is required for its proper localization to the cell membrane and cytoskeleton fractions in the thymocytes (By similarity). cytosol .
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