儲存： -15°C to -25°C/1 year(Do not lower than -25°C)
克隆性： Monoclonal
克隆號： PT0544R
特異性： Endogenous
基因名稱： CDKN1A CAP20 CDKN1 CIP1 MDA6 PIC1 SDI1 WAF1
蛋白名稱： p21
別名： Cyclin-dependent kinase inhibitor 1 ;CDK-interacting protein 1;Melanoma differentiation-associated protein 6;MDA-6;p21;
Organism-1： Human
基因ID-1： 1026
SwissProt-1： P38936
Organism-2： Mouse
基因ID-2： 12575
SwissProt-2： P39689
背景： This gene encodes a potent cyclin-dependent kinase inhibitor. The encoded protein binds to and inhibits the activity of cyclin-cyclin-dependent kinase2 or -cyclin-dependent kinase4 complexes, and thus functions as a regulator of cell cycle progression at G1. The expression of this gene is tightly controlled by the tumor suppressor protein p53, through which this protein mediates the p53-dependent cell cycle G1 phase arrest in response to a variety of stress stimuli. This protein can interact with proliferating cell nuclear antigen, a DNA polymerase accessory factor, and plays a regulatory role in S phase DNA replication and DNA damage repair. This protein was reported to be specifically cleaved by CASP3-like caspases, which thus leads to a dramatic activation of cyclin-dependent kinase2, and may be instrumental in the execution of apoptosis following caspase activation. Mice that lac
儲存： -15°C to -25°C/1 year(Do not lower than -25°C)
克隆性： Monoclonal
克隆號： PT0544R
特異性： Endogenous
基因名稱： CDKN1A CAP20 CDKN1 CIP1 MDA6 PIC1 SDI1 WAF1
蛋白名稱： p21
別名： Cyclin-dependent kinase inhibitor 1 ;CDK-interacting protein 1;Melanoma differentiation-associated protein 6;MDA-6;p21;
Organism-1： Human
基因ID-1： 1026
SwissProt-1： P38936
Organism-2： Mouse
基因ID-2： 12575
SwissProt-2： P39689
背景： This gene encodes a potent cyclin-dependent kinase inhibitor. The encoded protein binds to and inhibits the activity of cyclin-cyclin-dependent kinase2 or -cyclin-dependent kinase4 complexes, and thus functions as a regulator of cell cycle progression at G1. The expression of this gene is tightly controlled by the tumor suppressor protein p53, through which this protein mediates the p53-dependent cell cycle G1 phase arrest in response to a variety of stress stimuli. This protein can interact with proliferating cell nuclear antigen, a DNA polymerase accessory factor, and plays a regulatory role in S phase DNA replication and DNA damage repair. This protein was reported to be specifically cleaved by CASP3-like caspases, which thus leads to a dramatic activation of cyclin-dependent kinase2, and may be instrumental in the execution of apoptosis following caspase activation. Mice that lac
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