儲存： -15°C to -25°C/1 year(Do not lower than -25°C)
克隆性： Monoclonal
克隆號： PT0456R
特異性： Endogenous
基因名稱： TP53BP1
蛋白名稱： Tumor suppressor p53-binding protein 1
別名： TP53BP1;Tumor suppressor p53-binding protein 1;53BP1;p53-binding protein 1;p53BP1
Organism-1： Human
基因ID-1： 7158
SwissProt-1： Q12888
Organism-2： Mouse
基因ID-2： 27223
SwissProt-2： P70399
背景： This gene encodes a protein that functions in the DNA double-strand break repair pathway choice, promoting non-homologous end joining (NHEJ) pathways, and limiting homologous recombination. This protein plays multiple roles in the DNA damage response, including promoting checkpoint signaling following DNA damage, acting as a scaffold for recruitment of DNA damage response proteins to damaged chromatin, and promoting NHEJ pathways by limiting end resection following a double-strand break. These roles are also important during V(D)J recombination, class switch recombination and at unprotected telomeres. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2017]
儲存： -15°C to -25°C/1 year(Do not lower than -25°C)
克隆性： Monoclonal
克隆號： PT0456R
特異性： Endogenous
基因名稱： TP53BP1
蛋白名稱： Tumor suppressor p53-binding protein 1
別名： TP53BP1;Tumor suppressor p53-binding protein 1;53BP1;p53-binding protein 1;p53BP1
Organism-1： Human
基因ID-1： 7158
SwissProt-1： Q12888
Organism-2： Mouse
基因ID-2： 27223
SwissProt-2： P70399
背景： This gene encodes a protein that functions in the DNA double-strand break repair pathway choice, promoting non-homologous end joining (NHEJ) pathways, and limiting homologous recombination. This protein plays multiple roles in the DNA damage response, including promoting checkpoint signaling following DNA damage, acting as a scaffold for recruitment of DNA damage response proteins to damaged chromatin, and promoting NHEJ pathways by limiting end resection following a double-strand break. These roles are also important during V(D)J recombination, class switch recombination and at unprotected telomeres. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2017]
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