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PTEN Rabbit mAb
商品貨號： PRM8531
適 應 性： 人,小鼠,大鼠
WB IF ELISA IP
￥800元
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商品描述
  • 發(fā)貨日期： 現(xiàn)貨
  • 靶點-Target： PTEN
  • 反應性-Reactivity： 人,小鼠,大鼠
  • 應用-Applications： WB,IF,IP,ELISA
  • MW(Calculated)： 47kD
  • MW(Observed)： 56kD
  • 宿主物種-Host Species： Rabbit
  • 同種型-Isotype： IgG,Kappa
  • 偶聯(lián)-Conjugate： Unmodified
  • 推薦稀釋比： WB 1:1000-1:5000;IF 1:200-1:1000;ELISA 1:5000-1:20000;IP 1:50-1:200,
  • 組成： PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
  • 純化工藝： Protein A
  • 儲存： -15°C to -25°C/1 year(Do not lower than -25°C)
  • 克隆性： Monoclonal
  • 克隆號： PT0226R
  • 特異性： Endogenous
  • 基因名稱： PTEN MMAC1 TEP1
  • 蛋白名稱： Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN (Mutated in multiple advanced cancers 1) (Phosphatase and tensin homolog)
  • Organism-1： Human
  • 基因ID-1： 5728
  • SwissProt-1： P60484
  • Organism-2： Mouse
  • 基因ID-2： 19211
  • SwissProt-2： O08586
  • 背景： phosphatase and tensin homolog(PTEN) Homo sapiens This gene was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency. The protein encoded by this gene is a phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase. It contains a tensin like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. Unlike most of the protein tyrosine phosphatases, this protein preferentially dephosphorylates phosphoinositide substrates. It negatively regulates intracellular levels of phosphatidylinositol-3,4,5-trisphosphate in cells and functions as a tumor suppressor by negatively regulating AKT/PKB signaling pathway. The use of a non-canonical (CUG) upstream initiation site produces a longer isoform that initiates translation with a leucine, and is thought to be preferentially associated with the mitochondrial inner membrane. This longer isoform may help regulate ener
  • 細胞定位： Cytoplasm, Nuclear
PTEN Rabbit mAb
Catalog No PRM8531
Product information
  • 發(fā)貨日期： 現(xiàn)貨
  • 靶點-Target： PTEN
  • 反應性-Reactivity： 人,小鼠,大鼠
  • 應用-Applications： WB,IF,IP,ELISA
  • MW(Calculated)： 47kD
  • MW(Observed)： 56kD
  • 宿主物種-Host Species： Rabbit
  • 同種型-Isotype： IgG,Kappa
  • 偶聯(lián)-Conjugate： Unmodified
  • 推薦稀釋比： WB 1:1000-1:5000;IF 1:200-1:1000;ELISA 1:5000-1:20000;IP 1:50-1:200,
  • 組成： PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
  • 純化工藝： Protein A
  • 儲存： -15°C to -25°C/1 year(Do not lower than -25°C)
  • 克隆性： Monoclonal
  • 克隆號： PT0226R
  • 特異性： Endogenous
  • 基因名稱： PTEN MMAC1 TEP1
  • 蛋白名稱： Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN (Mutated in multiple advanced cancers 1) (Phosphatase and tensin homolog)
  • Organism-1： Human
  • 基因ID-1： 5728
  • SwissProt-1： P60484
  • Organism-2： Mouse
  • 基因ID-2： 19211
  • SwissProt-2： O08586
  • 背景： phosphatase and tensin homolog(PTEN) Homo sapiens This gene was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency. The protein encoded by this gene is a phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase. It contains a tensin like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. Unlike most of the protein tyrosine phosphatases, this protein preferentially dephosphorylates phosphoinositide substrates. It negatively regulates intracellular levels of phosphatidylinositol-3,4,5-trisphosphate in cells and functions as a tumor suppressor by negatively regulating AKT/PKB signaling pathway. The use of a non-canonical (CUG) upstream initiation site produces a longer isoform that initiates translation with a leucine, and is thought to be preferentially associated with the mitochondrial inner membrane. This longer isoform may help regulate ener
  • 細胞定位： Cytoplasm, Nuclear
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