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Cofilin Rabbit mAb
商品貨號(hào)： PRM8633
適 應(yīng) 性： 人,小鼠,大鼠
WB IHC IF ELISA IP
￥800元
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商品描述
  • 發(fā)貨日期： 現(xiàn)貨
  • 靶點(diǎn)-Target： Cofilin
  • 反應(yīng)性-Reactivity： 人,小鼠,大鼠
  • 應(yīng)用-Applications： WB,IHC,IF,IP,ELISA
  • MW(Calculated)： 19kD
  • MW(Observed)： 19kD
  • 宿主物種-Host Species： Rabbit
  • 同種型-Isotype： IgG,Kappa
  • 偶聯(lián)-Conjugate： Unmodified
  • 推薦稀釋比： IHC 1:20000-1:50000;WB 1:2000-1:10000;IF 1:200-1:1000;ELISA 1:5000-1:20000;IP 1:50-1:200;
  • 組成： PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
  • 純化工藝： Protein A
  • 儲(chǔ)存： -15°C to -25°C/1 year(Do not lower than -25°C)
  • 克隆號(hào)： PT0685R
  • 特異性： Endogenous
  • 基因名稱(chēng)： CFL1 CFL
  • 蛋白名稱(chēng)： Cofilin
  • 別名： Cofilin-1;18 kDa phosphoprotein;p18;Cofilin, non-muscle isoform;
  • Organism-1： Human
  • 基因ID-1： 1072
  • SwissProt-1： P23528
  • Organism-2： Mouse
  • 基因ID-2： 12631
  • SwissProt-2： P18760
  • Organism-3： Rat
  • 基因ID-3： 29271
  • SwissProt-3： P45592
  • 背景： cofilin 1(CFL1) Homo sapiens The protein encoded by this gene can polymerize and depolymerize F-actin and G-actin in a pH-dependent manner. Increased phosphorylation of this protein by LIM kinase aids in Rho-induced reorganization of the actin cytoskeleton. Cofilin is a widely distributed intracellular actin-modulating protein that binds and depolymerizes filamentous F-actin and inhibits the polymerization of monomeric G-actin in a pH-dependent manner. It is involved in the translocation of actin-cofilin complex from cytoplasm to nucleus.[supplied by OMIM, Apr 2004],
  • 細(xì)胞定位： Nucleus matrix . Cytoplasm, cytoskeleton . Cell projection, ruffle membrane ; Peripheral membrane protein ; Cytoplasmic side . Cell projection, lamellipodium membrane ; Peripheral membrane protein ; Cytoplasmic side . Cell projection, lamellipodium . Cell projection, growth cone . Cell projection, axon . Colocalizes with the actin cytoskeleton in membrane ruffles and lamellipodia. Detected at the cleavage furrow and contractile ring during cytokinesis. Almost completely in nucleus in cells exposed to heat shock or 10% dimethyl sulfoxide.
Cofilin Rabbit mAb
Catalog No PRM8633
Product information
  • 發(fā)貨日期： 現(xiàn)貨
  • 靶點(diǎn)-Target： Cofilin
  • 反應(yīng)性-Reactivity： 人,小鼠,大鼠
  • 應(yīng)用-Applications： WB,IHC,IF,IP,ELISA
  • MW(Calculated)： 19kD
  • MW(Observed)： 19kD
  • 宿主物種-Host Species： Rabbit
  • 同種型-Isotype： IgG,Kappa
  • 偶聯(lián)-Conjugate： Unmodified
  • 推薦稀釋比： IHC 1:20000-1:50000;WB 1:2000-1:10000;IF 1:200-1:1000;ELISA 1:5000-1:20000;IP 1:50-1:200;
  • 組成： PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
  • 純化工藝： Protein A
  • 儲(chǔ)存： -15°C to -25°C/1 year(Do not lower than -25°C)
  • 克隆號(hào)： PT0685R
  • 特異性： Endogenous
  • 基因名稱(chēng)： CFL1 CFL
  • 蛋白名稱(chēng)： Cofilin
  • 別名： Cofilin-1;18 kDa phosphoprotein;p18;Cofilin, non-muscle isoform;
  • Organism-1： Human
  • 基因ID-1： 1072
  • SwissProt-1： P23528
  • Organism-2： Mouse
  • 基因ID-2： 12631
  • SwissProt-2： P18760
  • Organism-3： Rat
  • 基因ID-3： 29271
  • SwissProt-3： P45592
  • 背景： cofilin 1(CFL1) Homo sapiens The protein encoded by this gene can polymerize and depolymerize F-actin and G-actin in a pH-dependent manner. Increased phosphorylation of this protein by LIM kinase aids in Rho-induced reorganization of the actin cytoskeleton. Cofilin is a widely distributed intracellular actin-modulating protein that binds and depolymerizes filamentous F-actin and inhibits the polymerization of monomeric G-actin in a pH-dependent manner. It is involved in the translocation of actin-cofilin complex from cytoplasm to nucleus.[supplied by OMIM, Apr 2004],
  • 細(xì)胞定位： Nucleus matrix . Cytoplasm, cytoskeleton . Cell projection, ruffle membrane ; Peripheral membrane protein ; Cytoplasmic side . Cell projection, lamellipodium membrane ; Peripheral membrane protein ; Cytoplasmic side . Cell projection, lamellipodium . Cell projection, growth cone . Cell projection, axon . Colocalizes with the actin cytoskeleton in membrane ruffles and lamellipodia. Detected at the cleavage furrow and contractile ring during cytokinesis. Almost completely in nucleus in cells exposed to heat shock or 10% dimethyl sulfoxide.
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