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PERK (Phospho Thr980) Rabbit mAb
商品貨號： PRM8647
適 應(yīng) 性： 小鼠,大鼠,
WB IF ELISA IP
￥7000元
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商品描述
  • 發(fā)貨日期： 現(xiàn)貨
  • 靶點(diǎn)-Target： PERK
  • 反應(yīng)性-Reactivity： 小鼠,大鼠,
  • 應(yīng)用-Applications： WB,IF,IP,ELISA
  • MW(Calculated)： 125kD
  • MW(Observed)： 125kD
  • 宿主物種-Host Species： Rabbit
  • 同種型-Isotype： IgG,Kappa
  • 偶聯(lián)-Conjugate： Phospho
  • 修飾-Modification： Thr980
  • 推薦稀釋比： WB 1:2000-1:10000;IF 1:200-1:1000;ELISA 1:5000-1:20000;IP 1:50-1:200;
  • 組成： PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
  • 純化工藝： Protein A
  • 儲存： -15°C to -25°C/1 year(Do not lower than -25°C)
  • 克隆號： PT0868R
  • 特異性： PERK (Phospho Thr980) Antibody detects endogenous levels of PERK protein only when phosphorylated at T980.The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):YArHT
  • 基因名稱： EIF2AK3
  • 蛋白名稱： Eukaryotic translation initiation factor 2-alpha kinase 3
  • 別名： EIF2AK3;PEK;PERK;Eukaryotic translation initiation factor 2-alpha kinase 3;PRKR-like endoplasmic reticulum kinase;Pancreatic eIF2-alpha kinase;HsPEK
  • Organism-1： Human
  • 基因ID-1： 9451
  • SwissProt-1： Q9NZJ5
  • Organism-2： Mouse
  • SwissProt-2： Q9Z2B5
  • Organism-3： Rat
  • 基因ID-3： 29702
  • SwissProt-3： Q9Z1Z1
  • 背景： The protein encoded by this gene phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2, leading to its inactivation, and thus to a rapid reduction of translational initiation and repression of global protein synthesis. This protein is thought to modulate mitochondrial function. It is a type I membrane protein located in the endoplasmic reticulum (ER), where it is induced by ER stress caused by malfolded proteins. Mutations in this gene are associated with Wolcott-Rallison syndrome. [provided by RefSeq, Sep 2015],
  • 細(xì)胞定位： Endoplasmic reticulum membrane; Single-pass type I membrane protein.
PERK (Phospho Thr980) Rabbit mAb
Catalog No PRM8647
Product information
  • 發(fā)貨日期： 現(xiàn)貨
  • 靶點(diǎn)-Target： PERK
  • 反應(yīng)性-Reactivity： 小鼠,大鼠,
  • 應(yīng)用-Applications： WB,IF,IP,ELISA
  • MW(Calculated)： 125kD
  • MW(Observed)： 125kD
  • 宿主物種-Host Species： Rabbit
  • 同種型-Isotype： IgG,Kappa
  • 偶聯(lián)-Conjugate： Phospho
  • 修飾-Modification： Thr980
  • 推薦稀釋比： WB 1:2000-1:10000;IF 1:200-1:1000;ELISA 1:5000-1:20000;IP 1:50-1:200;
  • 組成： PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
  • 純化工藝： Protein A
  • 儲存： -15°C to -25°C/1 year(Do not lower than -25°C)
  • 克隆號： PT0868R
  • 特異性： PERK (Phospho Thr980) Antibody detects endogenous levels of PERK protein only when phosphorylated at T980.The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):YArHT
  • 基因名稱： EIF2AK3
  • 蛋白名稱： Eukaryotic translation initiation factor 2-alpha kinase 3
  • 別名： EIF2AK3;PEK;PERK;Eukaryotic translation initiation factor 2-alpha kinase 3;PRKR-like endoplasmic reticulum kinase;Pancreatic eIF2-alpha kinase;HsPEK
  • Organism-1： Human
  • 基因ID-1： 9451
  • SwissProt-1： Q9NZJ5
  • Organism-2： Mouse
  • SwissProt-2： Q9Z2B5
  • Organism-3： Rat
  • 基因ID-3： 29702
  • SwissProt-3： Q9Z1Z1
  • 背景： The protein encoded by this gene phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2, leading to its inactivation, and thus to a rapid reduction of translational initiation and repression of global protein synthesis. This protein is thought to modulate mitochondrial function. It is a type I membrane protein located in the endoplasmic reticulum (ER), where it is induced by ER stress caused by malfolded proteins. Mutations in this gene are associated with Wolcott-Rallison syndrome. [provided by RefSeq, Sep 2015],
  • 細(xì)胞定位： Endoplasmic reticulum membrane; Single-pass type I membrane protein.
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