儲存： -15°C to -25°C/1 year(Do not lower than -25°C)
克隆號： PT0948R
特異性： Endogenous
基因名稱： APOE
蛋白名稱： Apolipoprotein E
別名： APOE;Apolipoprotein E;Apo-E
Organism-1： Human
基因ID-1： 348
SwissProt-1： P02649
Organism-2： Mouse
基因ID-2： 11816
SwissProt-2： P08226
Organism-3： Rat
基因ID-3： 25728
SwissProt-3： P02650
背景： The protein encoded by this gene is a major apoprotein of the chylomicron. It binds to a specific liver and peripheral cell receptor, and is essential for the normal catabolism of triglyceride-rich lipoprotein constituents. This gene maps to chromosome 19 in a cluster with the related apolipoprotein C1 and C2 genes. Mutations in this gene result in familial dysbetalipoproteinemia, or type III hyperlipoproteinemia (HLP III), in which increased plasma cholesterol and triglycerides are the consequence of impaired clearance of chylomicron and VLDL remnants. [provided by RefSeq, Jun 2016],
細胞定位： Secreted . Secreted, extracellular space . Secreted, extracellular space, extracellular matrix . In the plasma, APOE is associated with chylomicrons, chylomicrons remnants, VLDL, LDL and HDL lipoproteins (PubMed:1911868, PubMed:8340399). Lipid poor oligomeric APOE is associated with the extracellular matrix in a calcium- and heparan-sulfate proteoglycans-dependent manner (PubMed:9488694). Lipidation induces the release from the extracellular matrix (PubMed:9488694). .
儲存： -15°C to -25°C/1 year(Do not lower than -25°C)
克隆號： PT0948R
特異性： Endogenous
基因名稱： APOE
蛋白名稱： Apolipoprotein E
別名： APOE;Apolipoprotein E;Apo-E
Organism-1： Human
基因ID-1： 348
SwissProt-1： P02649
Organism-2： Mouse
基因ID-2： 11816
SwissProt-2： P08226
Organism-3： Rat
基因ID-3： 25728
SwissProt-3： P02650
背景： The protein encoded by this gene is a major apoprotein of the chylomicron. It binds to a specific liver and peripheral cell receptor, and is essential for the normal catabolism of triglyceride-rich lipoprotein constituents. This gene maps to chromosome 19 in a cluster with the related apolipoprotein C1 and C2 genes. Mutations in this gene result in familial dysbetalipoproteinemia, or type III hyperlipoproteinemia (HLP III), in which increased plasma cholesterol and triglycerides are the consequence of impaired clearance of chylomicron and VLDL remnants. [provided by RefSeq, Jun 2016],
細胞定位： Secreted . Secreted, extracellular space . Secreted, extracellular space, extracellular matrix . In the plasma, APOE is associated with chylomicrons, chylomicrons remnants, VLDL, LDL and HDL lipoproteins (PubMed:1911868, PubMed:8340399). Lipid poor oligomeric APOE is associated with the extracellular matrix in a calcium- and heparan-sulfate proteoglycans-dependent manner (PubMed:9488694). Lipidation induces the release from the extracellular matrix (PubMed:9488694). .
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