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STAT6 (Phospho Tyr641) Rabbit mAb
商品貨號： PRM8678
適 應(yīng) 性： 人,小鼠,大鼠
WB IHC IF ELISA IP
￥800元
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商品描述
  • 發(fā)貨日期： 現(xiàn)貨
  • 靶點-Target： Stat6
  • 反應(yīng)性-Reactivity： 人,小鼠,大鼠
  • 應(yīng)用-Applications： WB,IHC,IF,IP,ELISA
  • MW(Calculated)： 94kD
  • MW(Observed)： 110kD
  • 宿主物種-Host Species： Rabbit
  • 同種型-Isotype： IgG,Kappa
  • 偶聯(lián)-Conjugate： Phospho
  • 修飾-Modification： Tyr641
  • 推薦稀釋比： IHC 1:500-1:2000;WB 1:2000-1:10000;IF 1:200-1:1000;ELISA 1:5000-1:20000;IP 1:50-1:200;
  • 組成： PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
  • 純化工藝： Protein A
  • 儲存： -15°C to -25°C/1 year(Do not lower than -25°C)
  • 克隆號： PT0917R
  • 特異性： Phospho-Stat6 (Y641) Antibody detects endogenous levels of Stat6 protein only when phosphorylated at Y641.The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):RGyVP
  • 基因名稱： STAT6
  • 蛋白名稱： Signal transducer and activator of transcription 6
  • 別名： STAT6;Signal transducer and activator of transcription 6;IL-4 Stat
  • Organism-1： Human
  • 基因ID-1： 6778
  • SwissProt-1： P42226
  • Organism-2： Mouse
  • 基因ID-2： 20852
  • SwissProt-2： P52633
  • 背景： The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein plays a central role in exerting IL4 mediated biological responses. It is found to induce the expression of BCL2L1/BCL-X(L), which is responsible for the anti-apoptotic activity of IL4. Knockout studies in mice suggested the roles of this gene in differentiation of T helper 2 (Th2) cells, expression of cell surface markers, and class switch of immunoglobulins. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010],
  • 細胞定位： Cytoplasm. Nucleus. Translocated into the nucleus in response to phosphorylation.
STAT6 (Phospho Tyr641) Rabbit mAb
Catalog No PRM8678
Product information
  • 發(fā)貨日期： 現(xiàn)貨
  • 靶點-Target： Stat6
  • 反應(yīng)性-Reactivity： 人,小鼠,大鼠
  • 應(yīng)用-Applications： WB,IHC,IF,IP,ELISA
  • MW(Calculated)： 94kD
  • MW(Observed)： 110kD
  • 宿主物種-Host Species： Rabbit
  • 同種型-Isotype： IgG,Kappa
  • 偶聯(lián)-Conjugate： Phospho
  • 修飾-Modification： Tyr641
  • 推薦稀釋比： IHC 1:500-1:2000;WB 1:2000-1:10000;IF 1:200-1:1000;ELISA 1:5000-1:20000;IP 1:50-1:200;
  • 組成： PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
  • 純化工藝： Protein A
  • 儲存： -15°C to -25°C/1 year(Do not lower than -25°C)
  • 克隆號： PT0917R
  • 特異性： Phospho-Stat6 (Y641) Antibody detects endogenous levels of Stat6 protein only when phosphorylated at Y641.The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):RGyVP
  • 基因名稱： STAT6
  • 蛋白名稱： Signal transducer and activator of transcription 6
  • 別名： STAT6;Signal transducer and activator of transcription 6;IL-4 Stat
  • Organism-1： Human
  • 基因ID-1： 6778
  • SwissProt-1： P42226
  • Organism-2： Mouse
  • 基因ID-2： 20852
  • SwissProt-2： P52633
  • 背景： The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein plays a central role in exerting IL4 mediated biological responses. It is found to induce the expression of BCL2L1/BCL-X(L), which is responsible for the anti-apoptotic activity of IL4. Knockout studies in mice suggested the roles of this gene in differentiation of T helper 2 (Th2) cells, expression of cell surface markers, and class switch of immunoglobulins. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010],
  • 細胞定位： Cytoplasm. Nucleus. Translocated into the nucleus in response to phosphorylation.
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