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首頁 > 抗體 > 兔單抗 > Rpb1 (Phospho Ser5) Rabbit mAb
Rpb1 (Phospho Ser5) Rabbit mAb
商品貨號： PRM8692
適 應 性： 人,小鼠,大鼠
WB IHC IF ELISA IP
￥800元
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商品描述
  • 發貨日期： 現貨
  • 靶點-Target： Rpb1
  • 反應性-Reactivity： 人,小鼠,大鼠
  • 應用-Applications： WB,IHC,IF,IP,ELISA
  • MW(Calculated)： 217kD
  • MW(Observed)： 217kD
  • 宿主物種-Host Species： Rabbit
  • 同種型-Isotype： IgG,Kappa
  • 偶聯-Conjugate： Phospho
  • 修飾-Modification： Ser5
  • 推薦稀釋比： IHC 1:200-1:1000;WB 1:500-1:2000;IF 1:200-1:1000;ELISA 1:5000-1:20000;IP 1:50-1:200;
  • 組成： PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
  • 純化工藝： Protein A
  • 儲存： -15°C to -25°C/1 year(Do not lower than -25°C)
  • 克隆號： PT0923R
  • 特異性： Rpb1 (Phospho Ser5) Monoclonal Antibody detects endogenous levels of Rpb1 protein only when phosphorylated at Ser5.The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):GGgPP
  • 基因名稱： POLR2A POLR2
  • 蛋白名稱： Rpb1 CTD (Ser5)
  • 別名： DNA-directed RNA polymerase II subunit RPB1;RNA polymerase II subunit B1;DNA-directed RNA polymerase II subunit A;DNA-directed RNA polymerase III largest subunit;RNA-directed RNA polymerase II subunit RPB1;
  • Organism-1： Human
  • 基因ID-1： 5430
  • SwissProt-1： P24928
  • Organism-2： Mouse
  • 基因ID-2： 20020
  • SwissProt-2： P08775
  • 背景： This gene encodes the largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. The product of this gene contains a carboxy terminal domain composed of heptapeptide repeats that are essential for polymerase activity. These repeats contain serine and threonine residues that are phosphorylated in actively transcribing RNA polymerase. In addition, this subunit, in combination with several other polymerase subunits, forms the DNA binding domain of the polymerase, a groove in which the DNA template is transcribed into RNA. [provided by RefSeq, Jul 2008],
  • 細胞定位： Nucleus . Cytoplasm . Chromosome . Hypophosphorylated form is mainly found in the cytoplasm, while the hyperphosphorylated and active form is nuclear (PubMed:26566685). Co-localizes with kinase SRPK2 and helicase DDX23 at chromatin loci where unscheduled R-loops form (PubMed:28076779). .
Rpb1 (Phospho Ser5) Rabbit mAb
Catalog No PRM8692
Product information
  • 發貨日期： 現貨
  • 靶點-Target： Rpb1
  • 反應性-Reactivity： 人,小鼠,大鼠
  • 應用-Applications： WB,IHC,IF,IP,ELISA
  • MW(Calculated)： 217kD
  • MW(Observed)： 217kD
  • 宿主物種-Host Species： Rabbit
  • 同種型-Isotype： IgG,Kappa
  • 偶聯-Conjugate： Phospho
  • 修飾-Modification： Ser5
  • 推薦稀釋比： IHC 1:200-1:1000;WB 1:500-1:2000;IF 1:200-1:1000;ELISA 1:5000-1:20000;IP 1:50-1:200;
  • 組成： PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
  • 純化工藝： Protein A
  • 儲存： -15°C to -25°C/1 year(Do not lower than -25°C)
  • 克隆號： PT0923R
  • 特異性： Rpb1 (Phospho Ser5) Monoclonal Antibody detects endogenous levels of Rpb1 protein only when phosphorylated at Ser5.The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):GGgPP
  • 基因名稱： POLR2A POLR2
  • 蛋白名稱： Rpb1 CTD (Ser5)
  • 別名： DNA-directed RNA polymerase II subunit RPB1;RNA polymerase II subunit B1;DNA-directed RNA polymerase II subunit A;DNA-directed RNA polymerase III largest subunit;RNA-directed RNA polymerase II subunit RPB1;
  • Organism-1： Human
  • 基因ID-1： 5430
  • SwissProt-1： P24928
  • Organism-2： Mouse
  • 基因ID-2： 20020
  • SwissProt-2： P08775
  • 背景： This gene encodes the largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. The product of this gene contains a carboxy terminal domain composed of heptapeptide repeats that are essential for polymerase activity. These repeats contain serine and threonine residues that are phosphorylated in actively transcribing RNA polymerase. In addition, this subunit, in combination with several other polymerase subunits, forms the DNA binding domain of the polymerase, a groove in which the DNA template is transcribed into RNA. [provided by RefSeq, Jul 2008],
  • 細胞定位： Nucleus . Cytoplasm . Chromosome . Hypophosphorylated form is mainly found in the cytoplasm, while the hyperphosphorylated and active form is nuclear (PubMed:26566685). Co-localizes with kinase SRPK2 and helicase DDX23 at chromatin loci where unscheduled R-loops form (PubMed:28076779). .
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